+> **WARNING**: Models with unequal rates and/or frequencies (e.g., `GTR2+FO`, `MK+FO`, `GTRX+FQ`, `GTRX+FO`) should **never** be applied to general morphological characters (transformational morphological characters; for the term, see [Sereno, 2007]) as their state labels are fundamentally arbitrary. These models are for data with non-arbitrary state labels (e.g., recoded amino acids [for practical application, see [Najle et al., 2023]; [xgrau/recoded-mixture-models]] and certain types of genomic information). For morphological data, it is the common practice to apply the `MK+FQ` model with or without rate heterogeneity across characters parameters.
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