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@@ -528,11 +528,14 @@ Trimming alignment sites by likelihood
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<div class="hline"></div>
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Phylogenetic inference can be highly sensitive to fast-evolving, saturated or
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erroneous sites in a sequence alignment. To address this issue, IQ-TREE
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implements the **trimmed log-likelihood** method - a robust and dynamic approach
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that improves tree inference by selectively down-weighting problematic sites.
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This method works by dynamically excluding a user-defined proportion of sites
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erroneous sites in a sequence alignment. Many studies used Gblocks
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([Castresana, 2000]) or trimAl ([Capella-Gutiérrez et al., 2009])
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to trim alignment sites prior to phylogenetic reconstruction.
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Here, we present an alternative approach called **trimmed log-likelihood**, a
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robust phylogenetics method, that automatically detects and trims such sites
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during tree search directly.
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The trimed log-likelihood method works by dynamically excluding a user-defined proportion of sites
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with the lowest log-likelihood values during the tree search. As the search
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progresses, the likelihood of each site is recalculated at each step using
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current tree and model parameters. This ensures that site removal is always
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See [Command Reference](Command-Reference) for a complete list of all options available in IQ-TREE.
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[Capella-Gutiérrez et al., 2009]: https://doi.org/10.1093/bioinformatics/btp348
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[Castresana, 2000]: https://doi.org/10.1093/oxfordjournals.molbev.a026334
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[Gadagkar et al., 2005]: https://doi.org/10.1002/jez.b.21026
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[Kishino et al., 1990]: https://doi.org/10.1007/BF02109483
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[Kishino and Hasegawa, 1989]: https://doi.org/10.1007/BF02100115

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