@@ -528,11 +528,14 @@ Trimming alignment sites by likelihood
528528<div class =" hline " ></div >
529529
530530Phylogenetic inference can be highly sensitive to fast-evolving, saturated or
531- erroneous sites in a sequence alignment. To address this issue, IQ-TREE
532- implements the ** trimmed log-likelihood** method - a robust and dynamic approach
533- that improves tree inference by selectively down-weighting problematic sites.
534-
535- This method works by dynamically excluding a user-defined proportion of sites
531+ erroneous sites in a sequence alignment. Many studies used Gblocks
532+ ([ Castresana, 2000] ) or trimAl ([ Capella-Gutiérrez et al., 2009] )
533+ to trim alignment sites prior to phylogenetic reconstruction.
534+ Here, we present an alternative approach called ** trimmed log-likelihood** , a
535+ robust phylogenetics method, that automatically detects and trims such sites
536+ during tree search directly.
537+
538+ The trimed log-likelihood method works by dynamically excluding a user-defined proportion of sites
536539with the lowest log-likelihood values during the tree search. As the search
537540progresses, the likelihood of each site is recalculated at each step using
538541current tree and model parameters. This ensures that site removal is always
@@ -577,6 +580,8 @@ Where to go from here?
577580
578581See [ Command Reference] ( Command-Reference ) for a complete list of all options available in IQ-TREE.
579582
583+ [ Capella-Gutiérrez et al., 2009 ] : https://doi.org/10.1093/bioinformatics/btp348
584+ [ Castresana, 2000 ] : https://doi.org/10.1093/oxfordjournals.molbev.a026334
580585[ Gadagkar et al., 2005 ] : https://doi.org/10.1002/jez.b.21026
581586[ Kishino et al., 1990 ] : https://doi.org/10.1007/BF02109483
582587[ Kishino and Hasegawa, 1989 ] : https://doi.org/10.1007/BF02100115
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