|
| 1 | +The voxelwise modeling framework |
| 2 | +================================ |
| 3 | + |
| 4 | +VM Framework |
| 5 | +------------ |
| 6 | + |
| 7 | +Voxelwise modeling (VM) is a framework to perform functional magnetic resonance |
| 8 | +imaging (fMRI) data analysis. |
| 9 | +Over the years, VM has led to many high profile publications |
| 10 | +[1]_ [2]_ [3]_ [4]_ [5]_ [6]_ [7]_ [8]_ [9]_ [10]_ [11]_. |
| 11 | + |
| 12 | +[...] |
| 13 | + |
| 14 | +Critical improvements |
| 15 | +--------------------- |
| 16 | + |
| 17 | +VM provides multiple critical improvements over other approaches to fMRI data |
| 18 | +analysis: |
| 19 | + |
| 20 | +#. |
| 21 | + Most methods for analyzing fMRI data rely on simple contrasts |
| 22 | + between a small number of conditions. In contrast, VM can efficiently analyze |
| 23 | + many different stimulus and task features simultaneously. This framework |
| 24 | + enables the analysis of complex naturalistic stimuli and tasks which contain |
| 25 | + a large number of features; for example, VM has been used with naturalistic images |
| 26 | + [1]_ [2]_, movies [3]_, and stories [8]_. |
| 27 | + |
| 28 | +#. |
| 29 | + Unlike the traditional null hypothesis testing framework, VM is not prone |
| 30 | + to overfitting and type I error and generalizes to new subjects and stimuli . |
| 31 | + VM is a predictive modeling framework that |
| 32 | + evaluates model performance on a separate test data set not used during fitting. |
| 33 | + |
| 34 | +#. |
| 35 | + VM performs an analysis in each subject’s native brain space instead of lossily |
| 36 | + transforming subjects into a common group space. This allows VM to produce |
| 37 | + results with maximal spatial resolution. Each subject provides their own fit |
| 38 | + and test data, so every subject provides a complete replication of all |
| 39 | + hypothesis tests. |
| 40 | + |
| 41 | +#. |
| 42 | + VM produces high-dimensional functional maps rather than simple contrast |
| 43 | + maps or correlation matrices. These maps reflect the |
| 44 | + selectivity of each voxel to thousands of stimulus and task features spread |
| 45 | + across dozens of feature spaces. These functional maps are much more |
| 46 | + detailed than those produced using statistical parametric mapping (SPM), |
| 47 | + multivariate pattern analysis (MVPA), or representational similarity |
| 48 | + analysis (RSA). |
| 49 | + |
| 50 | +#. |
| 51 | + VM recovers stable and interpretable functional parcellations, which |
| 52 | + respect individual variability in anatomy [8]_. |
| 53 | + |
| 54 | + |
| 55 | +References |
| 56 | +---------- |
| 57 | + |
| 58 | +.. [1] Kay, K. N., Naselaris, T., Prenger, R. J., & Gallant, J. L. (2008). |
| 59 | + Identifying natural images from human brain activity. |
| 60 | + Nature, 452(7185), 352-355. |
| 61 | +
|
| 62 | +.. [2] Naselaris, T., Prenger, R. J., Kay, K. N., Oliver, M., & Gallant, J. L. (2009). |
| 63 | + Bayesian reconstruction of natural images from human brain activity. |
| 64 | + Neuron, 63(6), 902-915. |
| 65 | +
|
| 66 | +.. [3] Nishimoto, S., Vu, A. T., Naselaris, T., Benjamini, Y., Yu, B., & Gallant, J. L. (2011). |
| 67 | + Reconstructing visual experiences from brain activity evoked by natural movies. |
| 68 | + Current Biology, 21(19), 1641-1646. |
| 69 | +
|
| 70 | +.. [4] Huth, A. G., Nishimoto, S., Vu, A. T., & Gallant, J. L. (2012). |
| 71 | + A continuous semantic space describes the representation of thousands of |
| 72 | + object and action categories across the human brain. |
| 73 | + Neuron, 76(6), 1210-1224. |
| 74 | +
|
| 75 | +.. [5] Çukur, T., Nishimoto, S., Huth, A. G., & Gallant, J. L. (2013). |
| 76 | + Attention during natural vision warps semantic representation across the human brain. |
| 77 | + Nature neuroscience, 16(6), 763-770. |
| 78 | +
|
| 79 | +.. [6] Çukur, T., Huth, A. G., Nishimoto, S., & Gallant, J. L. (2013). |
| 80 | + Functional subdomains within human FFA. |
| 81 | + Journal of Neuroscience, 33(42), 16748-16766. |
| 82 | +
|
| 83 | +.. [7] Stansbury, D. E., Naselaris, T., & Gallant, J. L. (2013). |
| 84 | + Natural scene statistics account for the representation of scene categories |
| 85 | + in human visual cortex. |
| 86 | + Neuron, 79(5), 1025-1034 |
| 87 | +
|
| 88 | +.. [8] Huth, A. G., De Heer, W. A., Griffiths, T. L., Theunissen, F. E., & Gallant, J. L. (2016). |
| 89 | + Natural speech reveals the semantic maps that tile human cerebral cortex. |
| 90 | + Nature, 532(7600), 453-458. |
| 91 | +
|
| 92 | +.. [9] de Heer, W. A., Huth, A. G., Griffiths, T. L., Gallant, J. L., & Theunissen, F. E. (2017). |
| 93 | + The hierarchical cortical organization of human speech processing. |
| 94 | + Journal of Neuroscience, 37(27), 6539-6557. |
| 95 | +
|
| 96 | +.. [10] Lescroart, M. D., & Gallant, J. L. (2019). |
| 97 | + Human scene-selective areas represent 3D configurations of surfaces. |
| 98 | + Neuron, 101(1), 178-192. |
| 99 | +
|
| 100 | +.. [11] Deniz, F., Nunez-Elizalde, A. O., Huth, A. G., & Gallant, J. L. (2019). |
| 101 | + The representation of semantic information across human cerebral cortex |
| 102 | + during listening versus reading is invariant to stimulus modality. |
| 103 | + Journal of Neuroscience, 39(39), 7722-7736. |
0 commit comments