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| 1 | +test_that("Testing weights calculation", { |
| 2 | + |
| 3 | + # The following function is almost the same as gs_info_rd. |
| 4 | + # The only difference is that: |
| 5 | + # gs_info_rd returns `ans` |
| 6 | + # gs_info_rd_ returns `tbl` with out removing columns |
| 7 | + # If there is a suggested way to avoid copy-pasting these similar functions, please let me know! |
| 8 | + gs_info_rd_ <- function(p_c = tibble::tibble(stratum = "All", rate = .2), |
| 9 | + p_e = tibble::tibble(stratum = "All", rate = .15), |
| 10 | + n = tibble::tibble(stratum = "All", n = c(100, 200, 300), analysis = 1:3), |
| 11 | + rd0 = 0, ratio = 1, weight = c("unstratified", "ss", "invar", "mr")) { |
| 12 | + |
| 13 | + n_analysis <- max(n$analysis) |
| 14 | + weight <- match.arg(weight) |
| 15 | + |
| 16 | + # Pool the input arguments together ---- |
| 17 | + suppressMessages( |
| 18 | + tbl <- n |> |
| 19 | + left_join(p_c) |> |
| 20 | + rename(p_c = rate) |> |
| 21 | + left_join(p_e) |> |
| 22 | + rename(p_e = rate) |> |
| 23 | + left_join(if ("data.frame" %in% class(rd0)) { |
| 24 | + rd0 |
| 25 | + } else { |
| 26 | + tibble(analysis = 1:n_analysis, rd0 = rd0) |
| 27 | + }) |> |
| 28 | + mutate( |
| 29 | + n_e = n / (1 + ratio), |
| 30 | + n_c = n * ratio / (1 + ratio), |
| 31 | + d = ifelse(p_c > p_e, 1, -1), |
| 32 | + p_pool_per_k_per_s = (n_c * p_c + n_e * p_e) / n, |
| 33 | + p_e0 = (p_c + ratio * p_e - d * rd0) / (ratio + 1), |
| 34 | + p_c0 = p_e0 + d * rd0 |
| 35 | + ) |
| 36 | + ) |
| 37 | + |
| 38 | + # Calculate the variance of the risk difference ---- |
| 39 | + if (is.numeric(rd0) && rd0 == 0) { |
| 40 | + tbl <- tbl |> mutate( |
| 41 | + sigma2_H0_per_k_per_s = p_pool_per_k_per_s * (1 - p_pool_per_k_per_s) * (1 / n_c + 1 / n_e), |
| 42 | + sigma2_H1_per_k_per_s = p_c * (1 - p_c) / n_c + p_e * (1 - p_e) / n_e |
| 43 | + ) |
| 44 | + } else if ("data.frame" %in% class(rd0) || rd0 != 0) { |
| 45 | + tbl <- tbl |> mutate( |
| 46 | + sigma2_H0_per_k_per_s = p_c0 * (1 - p_c0) / n_c + p_e0 * (1 - p_e0) / n_e, |
| 47 | + sigma2_H1_per_k_per_s = p_c * (1 - p_c) / n_c + p_e * (1 - p_e) / n_e |
| 48 | + ) |
| 49 | + } |
| 50 | + |
| 51 | + # Assign weights ---- |
| 52 | + if (weight == "unstratified") { |
| 53 | + tbl <- tbl |> mutate(weight_per_k_per_s = 1) |
| 54 | + } else if (weight == "ss") { |
| 55 | + suppressMessages( |
| 56 | + tbl <- tbl |> |
| 57 | + left_join( |
| 58 | + tbl |> |
| 59 | + group_by(analysis) |> |
| 60 | + summarize(sum_ss = sum(n_c * n_e / (n_c + n_e))) |
| 61 | + ) |> |
| 62 | + mutate(weight_per_k_per_s = n_c * n_e / (n_c + n_e) / sum_ss) |> |
| 63 | + select(-sum_ss) |
| 64 | + ) |
| 65 | + } else if (weight == "invar") { |
| 66 | + suppressMessages( |
| 67 | + tbl <- tbl |> |
| 68 | + left_join( |
| 69 | + tbl |> |
| 70 | + group_by(analysis) |> |
| 71 | + summarize(sum_inv_var_per_s = sum(1 / sigma2_H1_per_k_per_s)) |
| 72 | + ) |> |
| 73 | + mutate(weight_per_k_per_s = 1 / sigma2_H1_per_k_per_s / sum_inv_var_per_s) |> |
| 74 | + select(-sum_inv_var_per_s) |
| 75 | + ) |
| 76 | + } else if (weight == "mr") { |
| 77 | + suppressMessages( |
| 78 | + tbl <- tbl |> |
| 79 | + left_join( |
| 80 | + tbl |> |
| 81 | + group_by(analysis) |> |
| 82 | + summarize(sum_inv_var_per_s = sum(1 / sigma2_H1_per_k_per_s)) |
| 83 | + ) |> |
| 84 | + ungroup() |> |
| 85 | + group_by(analysis) |> |
| 86 | + mutate(alpha_per_k_per_s = (p_e - p_c) * sum_inv_var_per_s - sum((p_e - p_c) / sigma2_H1_per_k_per_s), |
| 87 | + beta_per_k_per_s = 1/sigma2_H1_per_k_per_s * (1 + alpha_per_k_per_s * sum((p_e - p_c) * n / sum(n))), |
| 88 | + weight_per_k_per_s = beta_per_k_per_s / sum_inv_var_per_s - |
| 89 | + (alpha_per_k_per_s / sigma2_H1_per_k_per_s / (sum_inv_var_per_s + sum(alpha_per_k_per_s * (p_e - p_c) / sigma2_H1_per_k_per_s))) * |
| 90 | + (sum((p_e - p_c) * beta_per_k_per_s) / sum_inv_var_per_s) |
| 91 | + ) # |> |
| 92 | + # select(-c(sum_inv_var_per_s, alpha_per_k_per_s, beta_per_k_per_s)) |
| 93 | + ) |
| 94 | + } |
| 95 | + |
| 96 | + return(tbl) |
| 97 | + } |
| 98 | + |
| 99 | + # This example following the second example in the paper "Minimum risk weights for comparing treatments in stratified binomial trials" |
| 100 | + p_c <- data.frame(stratum = c("Stratum1", "Stratum2"), rate = c(0.48, 0.8)) |
| 101 | + p_e <- data.frame(stratum = c("Stratum1", "Stratum2"), rate = c(0.53, 0.95)) |
| 102 | + n <- data.frame(stratum = c("Stratum1", "Stratum2"), n = c(63, 37), analysis = 1) |
| 103 | + |
| 104 | + # Testing the INVAR weight |
| 105 | + weight_invar <- gs_info_rd_(p_c = p_c, p_e = p_e, n = n, rd0 = 0, ratio = 1, weight = "invar")$weight_per_k_per_s |
| 106 | + expect_equal(weight_invar, c(0.41, 0.59), tolerance = 1e-2) |
| 107 | + |
| 108 | + # Testing the SS weight |
| 109 | + weight_ss <- gs_info_rd_(p_c = p_c, p_e = p_e, n = n, rd0 = 0, ratio = 1, weight = "ss")$weight_per_k_per_s |
| 110 | + expect_equal(weight_ss, c(0.63, 0.37), tolerance = 1e-2) |
| 111 | + |
| 112 | + # Testing the MR weight following formula (10) |
| 113 | + x_mr <- gs_info_rd_(p_c = p_c, p_e = p_e, n = n, rd0 = 0, ratio = 1, weight = "mr") |
| 114 | + V1 <- x_mr$sigma2_H1_per_k_per_s[1] |
| 115 | + V2 <- x_mr$sigma2_H1_per_k_per_s[2] |
| 116 | + delta1 <- x_mr$p_e[1] - x_mr$p_c[1] |
| 117 | + delta2 <- x_mr$p_e[2] - x_mr$p_c[2] |
| 118 | + f1 <- x_mr$n[1] / sum(x_mr$n) |
| 119 | + f2 <- x_mr$n[2] / sum(x_mr$n) |
| 120 | + |
| 121 | + w1 <- (V2+(delta1-delta2)^2*f1) / (V1 + V2 + (delta1 - delta2)^2) |
| 122 | + w2 <- 1 - w1 |
| 123 | + expect_equal(gs_info_rd_(p_c = p_c, p_e = p_e, n = n, rd0 = 0, ratio = 1, weight = "mr")$weight_per_k_per_s, |
| 124 | + c(w1, w2)) |
| 125 | + |
| 126 | + # Note that if is risk difference is constant across strata,then alpha_per_k_per_s is zero |
| 127 | + expect_equal(gs_info_rd_(p_c = data.frame(stratum = c("Stratum1", "Stratum2"), rate = c(0.4, 0.8)), |
| 128 | + p_e = data.frame(stratum = c("Stratum1", "Stratum2"), rate = c(0.5, 0.9)), |
| 129 | + n = data.frame(stratum = c("Stratum1", "Stratum2"), n = c(50, 50), analysis = 1), |
| 130 | + rd0 = 0, ratio = 1, weight = "mr")$alpha_per_k_per_s, |
| 131 | + c(0, 0)) |
| 132 | + |
| 133 | + |
| 134 | +}) |
| 135 | + |
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