Using gChromVAR with a SummarizedExperiment that is backed by an HDF5Array (a DelayedArray implementation) can result in sending a DelayedMatrix object to some of the helper functions here (for example from here).
I believe it should be relatively straightforward to provide support for this, since it should be a matter of directing to use the DelayedMatrix implementations of colSums, rowSums in the helper_functions.R.
Using
gChromVARwith aSummarizedExperimentthat is backed by anHDF5Array(aDelayedArrayimplementation) can result in sending aDelayedMatrixobject to some of the helper functions here (for example from here).I believe it should be relatively straightforward to provide support for this, since it should be a matter of directing to use the
DelayedMatriximplementations ofcolSums,rowSumsin thehelper_functions.R.